Phenotypes Associated with This Genotype

Genotype
MGI:5431947

• Allelic Composition: Pten^tm1Rdp/Pten^tm1Rdp; Smad4^tm1Rdp/Smad4^tm1Rdp; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186105 )

• survival time is shorter than in mutant mice wild-type for Smad4

• median survival time of 17.05 weeks

neoplasm

increased prostate gland adenocarcinoma incidence ( J:186105 )

♂ • all develop rapidly progressive, locally invasive prostate adenocarcinomas

♂ • tumors are more aggressive than in mutant mice wild-type for Smad4

increased metastatic potential ( J:186105 )

• bone metastases are seen in some (3 of 24) mice unlike in mutant mice wild-type for Smad4

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:186105 )

♂ • all develop rapidly progressive, locally invasive prostate adenocarcinomas

♂ • tumors are more aggressive than in mutant mice wild-type for Smad4

reproductive system

increased prostate gland adenocarcinoma incidence ( J:186105 )

♂ • all develop rapidly progressive, locally invasive prostate adenocarcinomas

♂ • tumors are more aggressive than in mutant mice wild-type for Smad4