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Phenotypes Associated with This Genotype
Genotype
MGI:5431945
Allelic
Composition		 Ptentm1Rdp/Ptentm1Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rdp mutation (0 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186105 )
• median survival time of 26.3 weeks

neoplasm
increased prostate gland adenocarcinoma incidence ( J:186105 )
• all develop rapidly progressive, locally invasive prostate adenocarcinomas
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:186105 )
• all develop rapidly progressive, locally invasive prostate adenocarcinomas
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:186105 )
• all develop rapidly progressive, locally invasive prostate adenocarcinomas
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory