Phenotypes Associated with This Genotype

Genotype
MGI:5431943

• Allelic Composition: Pten^tm1Rdp/Pten^tm1Rdp; Tert^tm1Rdp/Tert^tm1Rdp; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:186105 )

♂ • at generations 3 and 4 (G3/4), all mice develop smaller, poorly progressive tumors compared to G0 mice

♂ • high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

♂ • most tumors fail to progress beyond HPIN by 24 weeks of age unlike in G0 mice

decreased tumor growth/size ( J:186105 )

• smaller, poorly progressive tumors compared to tumors in G0 mice

• markedly increased apoptosis and decreased proliferation in tumor cells compared tumor cells from G0 mice

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:186105 )

♂ • at generations 3 and 4 (G3/4), all mice develop smaller, poorly progressive tumors compared to G0 mice

♂ • high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

♂ • most tumors fail to progress beyond HPIN by 24 weeks of age unlike in G0 mice

cellular

decreased telomere length ( J:186105 )

• reduced at G3/4

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:186105 )

♂ • at generations 3 and 4 (G3/4), all mice develop smaller, poorly progressive tumors compared to G0 mice

♂ • high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

♂ • most tumors fail to progress beyond HPIN by 24 weeks of age unlike in G0 mice