Phenotypes Associated with This Genotype

Genotype
MGI:5431883

• Allelic Composition: Drd2^tm3.1Ebo/Drd2^tm3.1Ebo; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:185643 )

• mice treated with cocaine exhibit a blunted hyperactivity response compared with control mice

impaired behavioral response to anesthetic ( J:185643 )

• mice fail to exhibit catalepsy induced by haloperidol compared with control mice

impaired coordination ( J:185643 )

• on a rotarod

decreased locomotor activity ( J:185643 )

• in the home cage and open field

• in mice fed cocaine

nervous system

nervous system phenotype ( J:185643 )

N • mice exhibit normal dopamine levels

abnormal nervous system electrophysiology ( J:185643 )

• neurons exhibit smaller relative peak amplitudes compared with control neurons

homeostasis/metabolism

abnormal dopamine level ( J:185643 )

• dopamine overflow evoked by a single stimulus in the dorsal striatum (DSt) is decreased compared to in control mice

• quinpirole-treated mice exhibit attenuated inhibition of dopamine overflow compared with control mice

• mice exhibit lower AMP evoked dopamine release compared with control mice

• however, mice exhibit normal dopamine reuptake

decreased physiological sensitivity to xenobiotic ( J:185643 )

• mice fail to exhibit catalepsy induced by haloperidol compared with control mice

• mice treated with quinpirole exhibit less of a decreased in locomotion compared with control mice