Phenotypes Associated with This Genotype

Genotype
MGI:5431882

• Allelic Composition: Drd2^tm3.1Ebo/Drd2^tm3.1Ebo; En1^tm2(cre)Wrst/En1⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to xenobiotic ( J:185643 )

• mice fed cocaine exhibit increased locomotion compared with control mice

• mice exhibit enhanced response to nomifensine with greater relative contribution of dopamine transporter activity to peak amplitude compared with control mice

enhanced behavioral response to cocaine ( J:185643 )

• mice treated with cocaine exhibit increased hyperactivity compared with control mice

enhanced behavioral response to anesthetic ( J:185643 )

• mice exhibit increased catalepsy induced by haloperidol compared with control mice

hyperactivity ( J:185643 )

• in an open field

increased vertical activity ( J:185643 )

induced hyperactivity ( J:185643 )

• in mice fed cocaine

nervous system

abnormal nervous system electrophysiology ( J:185643 )

homeostasis/metabolism

abnormal dopamine level ( J:185643 )

• dopamine overflow evoked by a single stimulus in the dorsal striatum (DSt) is decreased compared to in control mice

• mice exhibit lower AMP evoked dopamine release compared with control mice

• dopamine reuptake is increased compared to in control mice

• mice exhibit enhanced response to nomifensine with greater relative contribution of dopamine transporter activity to peak amplitude compared with control mice

• following paired pulse, dopamine overflow is higher than in control mice

• single-pulse evoke dopamine overflow is decreased compared to in control mice

• multiple-pulse evoked dopamine overflow is increased compared to in wild-type mice

• however, quinpirole-treated mice exhibit normal dose-dependent inhibition of dopamine overflow

increased dopamine level ( J:185643 )

• in the nucleus accumbens (NAcc) and cortex

decreased physiological sensitivity to xenobiotic ( J:185643 )

• mice treated with quinpirole exhibit less of a decrease in locomotion compared with control mice

• mice treated with quinpirole in a novel environment fail to exhibit a decrease in locomotion compared with control mice