Phenotypes Associated with This Genotype

Genotype
MGI:5431541

• Allelic Composition: Rnaseh2b^{tm1a(EUCOMM)Wtsi}/Rnaseh2b^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0087_4_A02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:186986 )

• extended vessels

hemorrhage ( J:186986 )

mortality/aging

preweaning lethality ( J:186180 )

• crosses between heterozygotes fail to produce offspring

perinatal lethality, complete penetrance ( J:186986 )

• despite being present in Mendelian ratios at E14.5, mice die prior to or around birth

endocrine/exocrine glands

thymus hypoplasia ( J:186986 )

• hypocellular E18.5

embryo

embryonic growth retardation ( J:186180 )

decreased embryo size ( J:186180 )

cellular

decreased cell proliferation ( J:186180 )

• of mouse embryonic fibroblasts

decreased fibroblast proliferation ( J:186986 )

• of E14.5 fibroblasts, becoming more pronounced with increasing passage number

• however, no increase in apoptosis is observed

hematopoietic system

thymus hypoplasia ( J:186986 )

• hypocellular E18.5

homeostasis/metabolism

edema ( J:186986 )

growth/size/body

embryonic growth retardation ( J:186180 )

decreased embryo size ( J:186180 )

decreased birth body size ( J:186986 )

• as early as E14.5

immune system

thymus hypoplasia ( J:186986 )

• hypocellular E18.5

liver/biliary system

liver hypoplasia ( J:186986 )

• hypocellular E18.5