Phenotypes Associated with This Genotype

Genotype
MGI:5431086

• Allelic Composition: Fig4^tm1.1Mm/Fig4^tm1.1Mm; Tg(Syn1-cre)671Jxm/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:185989 )

• survival to 5 months of age but severely weakened

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:185989 )

• severe movement disorder by 30 days of age

limb grasping ( J:185989 )

• both forelimb and hind limb clasping in tail suspension tests at 3 months of age

nervous system

astrocytosis ( J:185989 )

• low level of astrocyte dysfunction

spongiform encephalopathy ( J:185989 )

• in deep layers of cortex, cerebellar nuclei, hippocampus, brainstem, and dorsal root ganglia

growth/size/body

decreased body weight ( J:185989 )

• body weight reductions are modest, weights of about 17g

integument

integument phenotype ( J:185989 )

N • normal coat color (not diluted)