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Phenotypes Associated with This Genotype
Genotype
MGI:5431005
Allelic
Composition
Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic
Background
FVB/N-Ak7Tg(tetO-Hmox1)67Sami
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ak7Tg(tetO-Hmox1)67Sami mutation (0 available); any Ak7 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of all mice die between 3 and 4 weeks of age
• however, mice with milder ventricular expansion survive more than 6 weeks

reproductive system
N
• female mice exhibit normal fertility
• by 42 days, mice exhibit almost complete absence of mature spermatids and spermatozoa in the seminiferous tubules and mature sperm in the epididymis

respiratory system
• reduced cilia beat frequency
• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice
• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice
• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice

nervous system
• after birth

growth/size/body
N
• mice do not exhibit situs invertus

renal/urinary system
N
• mice do not exhibit polycystic kidney disease

immune system
• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice
• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice
• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice

cellular
• reduced cilia beat frequency


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory