Mouse Genome Informatics
hm
    Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
FVB/N-Ak7Tg(tetO-Hmox1)67Sami
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• half of all mice die between 3 and 4 weeks of age
• however, mice with milder ventricular expansion survive more than 6 weeks

reproductive system
N
• female mice exhibit normal fertility (J:186062)
• by 42 days, mice exhibit almost complete absence of mature spermatids and spermatozoa in the seminiferous tubules and mature sperm in the epididymis (J:186062)
(J:186062)

respiratory system
• reduced cilia beat frequency
• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice
• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice
• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice

nervous system
• after birth

growth/size
N
• mice do not exhibit situs invertus (J:186062)

renal/urinary system
N
• mice do not exhibit polycystic kidney disease (J:186062)

immune system
• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice
• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice
• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice

cellular
• reduced cilia beat frequency

Mouse Models of Human Disease
OMIM IDRef(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:186062