Analysis Tools
mortality/aging
|
• half of all mice die between 3 and 4 weeks of age
• however, mice with milder ventricular expansion survive more than 6 weeks
|
reproductive system
| N |
• female mice exhibit normal fertility
|
azoospermia
(
J:186062
)
 |
• by 42 days, mice exhibit almost complete absence of mature spermatids and spermatozoa in the seminiferous tubules and mature sperm in the epididymis
|
respiratory system
|
• microtubule defects
|
|
• reduced cilia beat frequency
|
|
• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice
• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice
|
|
• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice
|
nervous system
hydrocephaly
(
J:186062
)
|
• after birth
|
|
• expanded
|
|
• compressed
|
growth/size/body
| N |
• mice do not exhibit situs invertus
|
renal/urinary system
| N |
• mice do not exhibit polycystic kidney disease
|
immune system
|
• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice
• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice
|
|
• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice
|
cellular
|
• microtubule defects
|
azoospermia
(
J:186062
)
|
|
• by 42 days, mice exhibit almost complete absence of mature spermatids and spermatozoa in the seminiferous tubules and mature sperm in the epididymis
|
|
• reduced cilia beat frequency
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary ciliary dyskinesia | DOID:9562 |
OMIM:PS244400 |
J:186062 | |
