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Phenotypes Associated with This Genotype
Genotype
MGI:5430804
Allelic
Composition
Adgrl3Gt(S17-5H1)Sor/Adgrl3Gt(S17-5H1)Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrl3Gt(S17-5H1)Sor mutation (0 available); any Adgrl3 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal working memory and motor coordination
• mice treated with cocaine exhibit increased horizontal activity compared with wild-type mice
• mice exhibit a greater instrumental responding for food indicating an increase in reward motivation
• mice take a longer time to become immobile within the first 2 min of the forced swim test and spend less time immobile in the last 4 min
• mice spend more time in the center of an open field than wild-type mice
• increased horizontal activity in an open field (J:185872)
• mice swim incessantly during a forced swim assay indicating an increase in activity levels (J:259247)
• mice treated with cocaine exhibit increased horizontal activity compared with wild-type mice

nervous system
• in the dorsal striatum
• primary cortical neurons show enhanced neurite outgrowth in culture with increased length and branching

homeostasis/metabolism
• low serum calcium levels
• however, vitamin D3 levels are normal
• in the dorsal striatum
• in the dorsal striatum


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory