Phenotypes Associated with This Genotype

Genotype
MGI:5430787

• Allelic Composition: Del(6Ephb6-Trpv6)2Mfre/Del(6Ephb6-Trpv6)2Mfre
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Prostate abnormalities in MGI:5430775/MGI:5430775 mice

reproductive system

reproductive system phenotype ( J:185629 )

N • mice exhibit normal testis size and spermatogenesis

necrospermia ( J:185629 )

♂ • reduced percentage of viable sperm in the cauda epididymis

asthenozoospermia ( J:185629 )

♂

abnormal prostate gland morphology ( J:185629 )

♂ • mice exhibit calcium depositions in the ventral, lateral and dorsal lobes of the prostate compared with wild-type mice

abnormal prostate gland duct morphology ( J:185629 )

♂ • enlarged

abnormal prostate gland epithelium morphology ( J:185629 )

♂ • loss of infoldings

abnormal epididymis epithelium morphology ( J:185629 )

♂ • impaired calcium absorption with increased calcium in the epididymal fluid

reduced male fertility ( J:185629 )

♂ • severe

impaired fertilization ( J:185629 )

decreased fertilization frequency ( J:185629 )

endocrine/exocrine glands

abnormal prostate gland morphology ( J:185629 )

♂ • mice exhibit calcium depositions in the ventral, lateral and dorsal lobes of the prostate compared with wild-type mice

abnormal prostate gland duct morphology ( J:185629 )

♂ • enlarged

abnormal prostate gland epithelium morphology ( J:185629 )

♂ • loss of infoldings

cellular

necrospermia ( J:185629 )

♂ • reduced percentage of viable sperm in the cauda epididymis

asthenozoospermia ( J:185629 )

♂