Phenotypes Associated with This Genotype

Genotype
MGI:5430594

• Allelic Composition: Dyrk1a^tm1Mla/Dyrk1a⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain size ( J:182294 )

• brains show shorter dorso-ventral length

abnormal thalamus morphology ( J:182294 )

• decrease in ventral posterolateral and ventral posteromedial thalamic nuclei volume (76% of control)

abnormal dentate gyrus morphology ( J:182294 )

• reduction in dentate gyrus volume (53% of control)

decreased hippocampus volume ( J:182294 )

• reduction in hippocampal CA1-CA3 volume (62% of control)

abnormal somatosensory cortex morphology ( J:182294 )

• decrease in cortical layer thickness at the somatosensory cortex; decrease in thickness of cortical layers II/III, V, and VI, but no difference in layer IV

• 25% decrease in thickness of cortical layers V and VI

• density of NeuN-labeled neurons in layers V and VI of the somatosensory cortex is increased by 27%, however density in layer II/III and IV is normal

• while there is a decrease in thickness of layers V and VI of the somatosensory cortex, the density of neurons in these layers is increased, indicating that the total number of neurons is unchanged