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Phenotypes Associated with This Genotype
Genotype
MGI:5430443
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (1062 available)
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal tubule morphology ( J:185844 )
• mice exhibit overproduction of a proximal tubule marker

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory