Phenotypes Associated with This Genotype

Genotype
MGI:5430365

• Allelic Composition: Tg(Pax6-HRAS*G12V)2044Ove/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Altered lens and corneal development inTg(Pax6-HRAS*G12V)2044Ove/0 mice

vision/eye

abnormal cornea epithelium morphology ( J:158529 )

• in the central cornea at E18.5

abnormal cornea stroma morphology ( J:158529 )

• in the central cornea at E18.5

abnormal eye development ( J:158529 )

• extra cells extending into the interior of the lens pit are seen at E10.5

• at E11.5, lenses and corneas display epithelial hyperplasia

• increase in proliferation of lens and corneal epithelial cells at E11.5 and E13.5

• expression analysis indicates abnormal differentiation of the cornea

abnormal lens development ( J:158529 )

• extra cells seen in the lens pit are internalized within the lumen of the lens at E11.5

• at E16.5 the lens epithelial show an elongated rather than cuboidal morphology

• expression analysis indicates abnormal differentiation of the lens

fused cornea and lens ( J:158529 )

• at E13.5 the lens is embedded in the cornea

• at E16.5 the lens remains attached to the cornea

lens vacuoles ( J:158529 )

• at E18.5

failure of eyelid fusion ( J:158529 )

• remain open at E16.5