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Phenotypes Associated with This Genotype
Genotype
MGI:5429853
Allelic
Composition
Akt2tm1Hem/Akt2tm1Hem
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1Hem mutation (0 available); any Akt2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• hyperplasia of spindle-like stromal cells
• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function
• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling
• ovarian cysts are characterized by thecal-interstitial hyperplasia
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants

homeostasis/metabolism
• aged females exhibit a 2-fold increase in serum testosterone levels

reproductive system
• hyperplasia of spindle-like stromal cells
• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function
• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling
• ovarian cysts are characterized by thecal-interstitial hyperplasia
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Ovary Syndrome 1; PCOS1 184700 J:185012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory