Mouse Genome Informatics
hm
    Akt2tm1Hem/Akt2tm1Hem
involves: 129P2/OlaHsd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• hyperplasia of spindle-like stromal cells
• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function
• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling
• ovarian cysts are characterized by thecal-interstitial hyperplasia
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants

homeostasis/metabolism
• aged females exhibit a 2-fold increase in serum testosterone levels

reproductive system
• hyperplasia of spindle-like stromal cells
• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function
• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling
• ovarian cysts are characterized by thecal-interstitial hyperplasia
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Ovary Syndrome 1; PCOS1 184700 J:185012