Phenotypes Associated with This Genotype

Genotype
MGI:5429768

• Allelic Composition: Aldh1a2^grim/Aldh1a2^grim
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185330 )

• die by E10.5

embryo

abnormal pharyngeal arch morphology ( J:185330 )

abnormal first pharyngeal arch morphology ( J:185330 )

• small and malformed

small first pharyngeal arch ( J:185330 )

absent pharyngeal arches ( J:185330 )

• in most embryos arches posterior to the first arch are absent

abnormal embryo turning ( J:185330 )

• defects in axial turning; however, a small degree if turning is seen

embryonic growth arrest ( J:185330 )

• at about E8.5 - E9.0

absent forelimb buds ( J:185330 )

• forelimb buds are small or absent

small forelimb buds ( J:185330 )

• forelimb buds are small or absent

decreased somite size ( J:185330 )

• small somites

cardiovascular system

failure of heart looping ( J:185330 )

• dilated unlooped hearts

abnormal heart tube morphology ( J:185330 )

• dilated unlooped hearts

hearing/vestibular/ear

abnormal otic vesicle morphology ( J:185330 )

• occasionally duplicated

small otic vesicle ( J:185330 )

• tiny

homeostasis/metabolism

abnormal vitamin A metabolism ( J:185330 )

• almost completely devoid of retinoic acid signaling

limbs/digits/tail

absent forelimb buds ( J:185330 )

• forelimb buds are small or absent

small forelimb buds ( J:185330 )

• forelimb buds are small or absent

craniofacial

abnormal pharyngeal arch morphology ( J:185330 )

abnormal first pharyngeal arch morphology ( J:185330 )

• small and malformed

small first pharyngeal arch ( J:185330 )

absent pharyngeal arches ( J:185330 )

• in most embryos arches posterior to the first arch are absent