Analysis Tools
behavior/neurological
| N |
• mice do not exhibit a deterioration in grip strength as compared to controls
• stride length, splay length and base are similar to controls
• rearing activity is similar to controls
• mice do not behave differently from controls in the light/dark choice test
|
|
• mice do not perform as well on rotarod test as controls, but performance does not worsen with age
• females perform worse than males
|
|
• mice are hypoactive (total distance covered) in the open field test starting at 12 weeks of age in the light phase and 8,16 and 34 weeks in the dark phase
• hypoactivity in the center is only observed in the dark phase at 16 and 34 weeks
|
growth/size/body
|
• body weight is significantly increased in males at 8 weeks and females at 16 weeks, although male weight does not reach significance at 56 weeks
|
nervous system
| N |
• mice do not exhibit alterations in startle reflex although there is significant variability across age and gender
|
|
• observed at 56 weeks of age
|
