Phenotypes Associated with This Genotype

Genotype
MGI:5429342

• Allelic Composition: Tg(LYZ-rtTA2S*M2,tetO-ELAVL1)632Dkon/0
• Genetic Background: B6.Cg-Tg(LYZ-rtTA2S*M2,tetO-ELAVL1)632Dkon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:184388 )

• doxycycline-treated mice exposed to DSS and DMH exhibit attenuated (reduced number, size and grade) colitis-associated cancer compared with control mice

decreased tumor growth/size ( J:184388 )

• in doxycycline-treated mice exposed to DSS and DMH

digestive/alimentary system

decreased susceptibility to induced colitis ( J:184388 )

• doxycycline-treated mice exposed to DSS exhibit delayed onset and severity of inflammatory bowel disease compared with controls

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:184388 )

• doxycycline-treated mice exposed to DSS and DMH exhibit attenuated (reduced number, size and grade) colitis-associated cancer compared with control mice

immune system

decreased susceptibility to induced colitis ( J:184388 )

• doxycycline-treated mice exposed to DSS exhibit delayed onset and severity of inflammatory bowel disease compared with controls