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Phenotypes Associated with This Genotype
Genotype
MGI:5429192
Allelic
Composition		 Prkdcm1Btlr/Prkdcm1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcm1Btlr mutation (1 available); any Prkdc mutation (408 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased B cell number ( J:185495 )
• severe B cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased B cell number ( J:185495 )
• severe B cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory