Phenotypes Associated with This Genotype

Genotype
MGI:5429187

• Allelic Composition: Dock2^m2Btlr/Dock2^m2Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:185495 )

N • mice exhibit a normal response to NP-Ficoll

abnormal B cell differentiation ( J:185495 )

• flow cytometry analysis of blood revealed low expression of B220 suggesting a block in B cell maturation compared with wild-type mice

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• low B220

decreased T cell number ( J:185495 )

• T cell deficiency

abnormal humoral immune response ( J:185495 )

• mice lack a T-dependent IgG response to model antigens encoded by a recombinant nonreplicating Semliki Forest Virus vector compared with wild-type mice

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system

abnormal B cell differentiation ( J:185495 )

• flow cytometry analysis of blood revealed low expression of B220 suggesting a block in B cell maturation compared with wild-type mice

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• low B220

decreased T cell number ( J:185495 )

• T cell deficiency

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen