Phenotypes Associated with This Genotype

Genotype
MGI:5429174

• Allelic Composition: Nfkbid^m1Btlr/Nfkbid^m1Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:185495 )

N • mice exhibit normal peripheral blood lymphocytes

N • B cell development is normal

N • in response to recombinant Semliki Forest virus (SFV) encoded antigen, mice produce normal levels of IgA, IgG1, IgG2a and IgG2b

increased B cell apoptosis ( J:185495 )

• in unstimulated cells

decreased B cell proliferation ( J:185495 )

• in response to LPS

• however, proliferation is normal in response to F(ab')alphaIgM (even when limiting)

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B-1 B cell number ( J:185495 )

• severe in the peritoneum

decreased B-1a cell number ( J:185495 )

• in the peritoneum

absent marginal zone B cells ( J:185495 )

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgG1 level ( J:185495 )

• 7 days following NP-CGG immunization

• however, levels were normal by day 14

decreased IgG3 level ( J:185495 )

• basal

decreased IgM level ( J:185495 )

• basal and following NP-Ficoll or NP-CGG immunization

cellular

increased B cell apoptosis ( J:185495 )

• in unstimulated cells

decreased B cell proliferation ( J:185495 )

• in response to LPS

• however, proliferation is normal in response to F(ab')alphaIgM (even when limiting)

hematopoietic system

increased B cell apoptosis ( J:185495 )

• in unstimulated cells

decreased B cell proliferation ( J:185495 )

• in response to LPS

• however, proliferation is normal in response to F(ab')alphaIgM (even when limiting)

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B-1 B cell number ( J:185495 )

• severe in the peritoneum

decreased B-1a cell number ( J:185495 )

• in the peritoneum

absent marginal zone B cells ( J:185495 )

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgG1 level ( J:185495 )

• 7 days following NP-CGG immunization

• however, levels were normal by day 14

decreased IgG3 level ( J:185495 )

• basal

decreased IgM level ( J:185495 )

• basal and following NP-Ficoll or NP-CGG immunization