Phenotypes Associated with This Genotype

Genotype
MGI:5429173

• Allelic Composition: Zeb1^m1Btlr/Zeb1^m1Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:185495 )

N • B cell development is normal

N • splenic T cell frequencies are normal

decreased B cell proliferation ( J:185495 )

• in response to B cell receptor cross-linking when the amount of F(ab')alphaIgM is limiting

• in response to LPS

• however, proliferation is normal in response to CpG

increased thymocyte number ( J:185495 )

abnormal B cell differentiation ( J:185495 )

• slight block

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased double-positive T cell number ( J:185495 )

decreased germinal center B cell number ( J:185495 )

• following NP-CGG immunization, splenic B cells reduced ability to transfer NP-specific memory to naive recipients compared with wild-type cells

decreased B-1 B cell number ( J:185495 )

• severe in the peritoneum

decreased B-1a cell number ( J:185495 )

• severe in the peritoneum

decreased B-1b cell number ( J:185495 )

• severe in the peritoneum

absent marginal zone B cells ( J:185495 )

decreased NK cell number ( J:185495 )

• in the spleen

increased single-positive T cell number ( J:185495 )

• in the thymus

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgG1 level ( J:185495 )

• following NP-CGG immunization

decreased IgM level ( J:185495 )

• following NP-Ficoll or NP-CGG immunization

abnormal memory B cell physiology ( J:185495 )

• following NP-CGG immunization, splenic B cells reduced ability to transfer NP-specific memory to na[?]ve recipients compared with wild-type cells

hematopoietic system

decreased B cell proliferation ( J:185495 )

• in response to B cell receptor cross-linking when the amount of F(ab')alphaIgM is limiting

• in response to LPS

• however, proliferation is normal in response to CpG

increased thymocyte number ( J:185495 )

abnormal B cell differentiation ( J:185495 )

• slight block

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased double-positive T cell number ( J:185495 )

decreased germinal center B cell number ( J:185495 )

• following NP-CGG immunization, splenic B cells reduced ability to transfer NP-specific memory to naive recipients compared with wild-type cells

decreased B-1 B cell number ( J:185495 )

• severe in the peritoneum

decreased B-1a cell number ( J:185495 )

• severe in the peritoneum

decreased B-1b cell number ( J:185495 )

• severe in the peritoneum

absent marginal zone B cells ( J:185495 )

decreased NK cell number ( J:185495 )

• in the spleen

increased single-positive T cell number ( J:185495 )

• in the thymus

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgG1 level ( J:185495 )

• following NP-CGG immunization

decreased IgM level ( J:185495 )

• following NP-Ficoll or NP-CGG immunization

abnormal memory B cell physiology ( J:185495 )

• following NP-CGG immunization, splenic B cells reduced ability to transfer NP-specific memory to na[?]ve recipients compared with wild-type cells

endocrine/exocrine glands

increased thymocyte number ( J:185495 )

cellular

decreased B cell proliferation ( J:185495 )

• in response to B cell receptor cross-linking when the amount of F(ab')alphaIgM is limiting

• in response to LPS

• however, proliferation is normal in response to CpG