Phenotypes Associated with This Genotype

Genotype
MGI:5429170

• Allelic Composition: Gsk3b^tm2Jrw/Gsk3b^tm2Jrw; Tg(Ggt1-cre)M3Egn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:167190 )

N • mutant kidneys are normal in terms of gross appearance, size, color, and glomerular and tubulointerstitial histology

N • kidney function, urine albumin excretion, and urine-concentrating ability remain normal

abnormal renal tubule morphology ( J:167190 )

• mice exhibit increased glycogen content in the renal cortical tubules, as shown by PAS staining and biochemical analysis

• EM revealed increased deposition of glycogen particles closely associated with tubules of smooth endoplasmic reticulum

abnormal proximal convoluted tubule morphology ( J:167190 )

• intense glycogen staining is primarily detected in the brush border of the renal tubules

homeostasis/metabolism

increased glycogen level ( J:167190 )

• mice exhibit increased glycogen accumulation in the renal cortical tubules