Analysis Tools
behavior/neurological
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• retention is reduced in passive avoidance tests involving electric shock training to prevent movement from a lighted area to a dark chamber
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• retention of spatial memory in T-water maze tests declines as early as 3 months after acquisition, faster than for transgenics alone
• acquisition of spatial memory in T-water maze tests is normal
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nervous system
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• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months
• higher brain levels of Abeta1-42
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homeostasis/metabolism
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• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months
• higher brain levels of Abeta1-42
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