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Phenotypes Associated with This Genotype
Genotype
MGI:5428441
Allelic
Composition
Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1+
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1.1Doi mutation (2 available); any Aire mutation (20 available)
Il1r1tm1Imx mutation (4 available); any Il1r1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• inflammation damages the tear-secreting acinar cells and interlobular septa
• progresses from desiccation and keratinization of the ocular surface
• desiccation and keratinization of the ocular surface
• ocular surface epitheliopathy
• inflammation damages the tear-secreting acinar cells and interlobular septa
• mice exhibit an increase in acidified conjunctival goblet cells compared with wild-type mice
• however, the total number of goblet cells is normal
• ocular mucosal epithelia metaplasia
• squamous metaplasia

endocrine/exocrine glands
• inflammation damages the tear-secreting acinar cells and interlobular septa
• inflammation damages the tear-secreting acinar cells and interlobular septa

immune system
• inflammation damages the tear-secreting acinar cells and interlobular septa

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:163691


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory