Mouse Genome Informatics
cx
    Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1+

involves: 129S2/SvPas * 129S7/SvEvBrd * NOD
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• inflammation damages the tear-secreting acinar cells and interlobular septa
• inflammation damages the tear-secreting acinar cells and interlobular septa
• mice exhibit an increase in acidified conjunctival goblet cells compared with wild-type mice
• however, the total number of goblet cells is normal
• desiccation and keratinization of the ocular surface
• ocular mucosal epithelia metaplasia
• ocular surface epitheliopathy
• squamous metaplasia
• progresses from desiccation and keratinization of the ocular surface

endocrine/exocrine glands
• inflammation damages the tear-secreting acinar cells and interlobular septa
• inflammation damages the tear-secreting acinar cells and interlobular septa

immune system
• inflammation damages the tear-secreting acinar cells and interlobular septa

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:163691