Mouse Genome Informatics
cx
    Apoetm1Unc/Apoetm1Unc
Cyp19a1tm1Esi/Cyp19a1tm1Esi

involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• increased body weight at 3, 6, and 12 months of age

cardiovascular system
• 3 month old mutants exhibit small aortic root lesions that are extensive at 6 months of age
• double mutants tend to have slightly larger lesion sizes than single Apoe mutants
• mutants develop large atherosclerotic lesions in the aortic root by 12 months of age; lesions are advanced in development and show a clear fibrous component
• however there is little evidence of atherosclerotic plaque formation within the thoracic aorta with only small lesion development seen in the thoracic aorta at 12 months of age
• mutants have moderately increased mean arterial blood pressure at 3 months of age
• mutants develop hypertension by 6 months of age which is sustained in older animals

adipose tissue
• mutants exhibit an increase in adipocyte size with a larger mean diameter compared to wild-type adipocytes, however no difference in the number of individual adipocytes
• increase in gonadal adipose

homeostasis/metabolism
• 3 month old mutants show a small elevation in baseline blood glucose concentration after an overnight fast
• mutants of all ages show reduced plasma insulin levels
• random-fed non-fasting mutants show an increase in serum cholesterol levels
• plasma levels of C-reactive protrein (CRP), IL-6, and TNF-alpha are increased in 12 month old mutants
• mutants administered a bolus of glucose show elevated plasma glucose
• 3 month old mutants show a blunted plasma glucose response in response to exogenous insulin administration; this blunted response becomes more pronounced with age

immune system
• plasma levels of C-reactive protrein (CRP), IL-6, and TNF-alpha are increased in 12 month old mutants

liver/biliary system
• from 6 months of age, livers begin to show yellow coloration
• increase in liver weight at 3 and 6 months of age
• 3 month old mutants start to show small lipid droplets forming within livers which become more pronounced at 6 and 12 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Abdominal Obesity-Metabolic Syndrome 605552 J:184647