Phenotypes Associated with This Genotype

Genotype
MGI:5428212

• Allelic Composition: Apc2^tm1Mno/Apc2^tm1Mno
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:184856 )

• sometimes seen

increased neuron apoptosis ( J:184856 )

• in the cerebral cortex

abnormal neuronal migration ( J:184856 )

• migration of cerebral cortical neurons is continuously altered with neurons born at E13.5 distributed in all layers of the cortex

• somal translocation appears normal but later born neurons, that migrate along radial glial fibers, are randomly distributed

abnormal cerebellar granule cell migration ( J:184856 )

• impaired in vivo

• in vitro migration is not enhanced by a BDNF gradient and not inhibited by SLIT2; however, in vitro basal migration and neurite outgrowth is similar to wild-type controls

• actin reorganization following BDNF or SLIT2 treatment is abnormal

abnormal dentate gyrus morphology ( J:184856 )

• dentate granule cells are less densely packed at P30

abnormal hippocampus layer morphology ( J:184856 )

• disorganized lamination

• marked invasion of the stratum oriens by pyramidal cells in the CA1 region at P30

abnormal hippocampus granule cell layer ( J:184856 )

• dentate granule cells are less densely packed at P30

abnormal hippocampus pyramidal cell layer ( J:184856 )

• diffusely split pyramidal cells in the CA3 region

ectopic hippocampus pyramidal cells ( J:184856 )

• at P20

• marked invasion of the stratum oriens by pyramidal cells in the CA1 region at P30

abnormal stratification in cerebral cortex ( J:184856 )

• disorganized lamination with blurred or indistinct boundaries between layers

• neuronal populations are highly intermingled

• at E15.5 the subplate layer is not visible

loss of cortex neurons ( J:184856 )

• decrease in the number of post mitotic neurons, especially in areas 1 and 2

abnormal olfactory bulb layer morphology ( J:184856 )

• disorganized lamination

abnormal olfactory bulb mitral cell layer morphology ( J:184856 )

• mitral cells are scattered failing to form a single layer

abnormal cerebellar layer morphology ( J:184856 )

• disorganized lamination

ectopic Purkinje cell ( J:184856 )

• at P20

ectopic cerebellar granule cells ( J:184856 )

• at P20

behavior/neurological

impaired coordination ( J:184856 )

• decrease in the latency to fall and an increase in the number of falls in a rotarod assay

long stride length ( J:184856 )

• longer hind limb stride

seizures ( J:184856 )

• sometimes seen

growth/size/body

postnatal growth retardation ( J:184856 )

• gradual

reproductive system

abnormal fertility/fecundity ( J:184856 )

• crosses of homozygous mice are unsuccessful

• however, homozygotes are fertile when crossed to heterozygous or wild-type mice

cellular

increased neuron apoptosis ( J:184856 )

• in the cerebral cortex

abnormal neuronal migration ( J:184856 )

• migration of cerebral cortical neurons is continuously altered with neurons born at E13.5 distributed in all layers of the cortex

• somal translocation appears normal but later born neurons, that migrate along radial glial fibers, are randomly distributed

abnormal cerebellar granule cell migration ( J:184856 )

• impaired in vivo

• in vitro migration is not enhanced by a BDNF gradient and not inhibited by SLIT2; however, in vitro basal migration and neurite outgrowth is similar to wild-type controls

• actin reorganization following BDNF or SLIT2 treatment is abnormal