Phenotypes Associated with This Genotype

Genotype
MGI:5428201

• Allelic Composition: Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
• Genetic Background: C.129P2-Il1rl1^tm1Anjm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased susceptibility to induced pancreatitis ( J:184801 )

• 72 hours after a choline-deficient-ethionine-supplemented (CDE) diet, mutants exhibit more severe necrosis, inflammation, and edema in the pancreas and higher levels of hydrolases and serum IL-6 than wild-type mice, indicating increased susceptibility to development of acute pancreatitis

• mutants present more severe pancreatitis disease after 10 hourly cerulean injections compared to wild-type mice, with higher hydrolase levels, higher edema, inflammation and necrosis

• mutants induced to develop acute pancreatitis, exhibit a greater increase in tryptase levels than wild-type mice, indicating an increase in mast cell activation

immune system

increased susceptibility to induced pancreatitis ( J:184801 )

• 72 hours after a choline-deficient-ethionine-supplemented (CDE) diet, mutants exhibit more severe necrosis, inflammation, and edema in the pancreas and higher levels of hydrolases and serum IL-6 than wild-type mice, indicating increased susceptibility to development of acute pancreatitis

• mutants present more severe pancreatitis disease after 10 hourly cerulean injections compared to wild-type mice, with higher hydrolase levels, higher edema, inflammation and necrosis

• mutants induced to develop acute pancreatitis, exhibit a greater increase in tryptase levels than wild-type mice, indicating an increase in mast cell activation