Phenotypes Associated with This Genotype

Genotype
MGI:5427951

• Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk; Sle21^129P2/Ola/Sle21^129P2/Ola
• Genetic Background: B6.129S4-Fcgr2b^tm1Ttk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:179175 )

• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice

immune system

enlarged spleen ( J:179175 )

• spontaneously

increased spleen weight ( J:179175 )

• spontaneously

abnormal adaptive immunity ( J:179175 )

• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice

increased immunoglobulin level ( J:179175 )

• kidney IgG and C3 depositions in a nephrotoxic nephritis model

increased IgG2a level ( J:179175 )

• in a nephrotoxic nephritis model that is more severe than in Fcgr2b^tm1.2Sjv homozygotes

increased susceptibility to induced arthritis ( J:179175 )

• collagen or K/BXN serum-induced that is more severe than in Fcgr2b^tm1.2Sjv homozygotes

increased susceptibility to systemic lupus erythematosus ( J:179175 )

• fatal lupus

increased autoantibody level ( J:179175 )

• spontaneous increase in Coombs, chromatin, double-strand DNA, single-strand DNA and histone autoantibodies

increased anti-chromatin antibody level ( J:179175 )

• spontaneously

increased anti-double stranded DNA antibody level ( J:179175 )

• spontaneously

increased anti-histone antibody level ( J:179175 )

• spontaneously

increased anti-single stranded DNA antibody level ( J:179175 )

• spontaneously

kidney inflammation ( J:179175 )

• in a nephrotoxic nephritis model that is more severe than in Fcgr2b^tm1.2Sjv homozygotes

renal/urinary system

albuminuria ( J:179175 )

• in a nephrotoxic nephritis model

kidney inflammation ( J:179175 )

• in a nephrotoxic nephritis model that is more severe than in Fcgr2b^tm1.2Sjv homozygotes

abnormal renal glomerulus morphology ( J:179175 )

• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice

homeostasis/metabolism

abnormal glomerular capillary thrombosis ( J:179175 )

• in a nephrotoxic nephritis model

albuminuria ( J:179175 )

• in a nephrotoxic nephritis model

skeleton

increased susceptibility to induced arthritis ( J:179175 )

• collagen or K/BXN serum-induced that is more severe than in Fcgr2b^tm1.2Sjv homozygotes

hematopoietic system

enlarged spleen ( J:179175 )

• spontaneously

increased spleen weight ( J:179175 )

• spontaneously

increased immunoglobulin level ( J:179175 )

• kidney IgG and C3 depositions in a nephrotoxic nephritis model

increased IgG2a level ( J:179175 )

• in a nephrotoxic nephritis model that is more severe than in Fcgr2b^tm1.2Sjv homozygotes

growth/size/body

enlarged spleen ( J:179175 )

• spontaneously

increased spleen weight ( J:179175 )

• spontaneously