About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5427950
Allelic
Composition		 Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
Genetic
Background		 involves: C57BL/6 * FVB/N * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Yaa mutation (23 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• mice exhibit greater cumulative death compared with Fcgr2btm1.2Sjv homozygotes

immune system
enlarged spleen ( J:179175 )
• compared with Fcgr2btm1.2Sjv homozygotes
increased monocyte cell number ( J:179175 )
• compared with single homozygotes
increased susceptibility to systemic lupus erythematosus ( J:179175 )
• mice develop moderate lupus unlike Fcgr2btm1.2Sjv homozygotes
• however, mice do not develop fatal lupus
increased anti-chromatin antibody level ( J:179175 )
• compared with single homozygotes
increased anti-double stranded DNA antibody level ( J:179175 )
• compared with single homozygotes

renal/urinary system
abnormal kidney morphology ( J:179175 )
• kidney pathology is increased compared to in Fcgr2btm1.2Sjv homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• compared with Fcgr2btm1.2Sjv homozygotes
increased monocyte cell number ( J:179175 )
• compared with single homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• compared with Fcgr2btm1.2Sjv homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory