Phenotypes Associated with This Genotype

Genotype
MGI:5427925

• Allelic Composition: Mirc21^tm1.1Kry/Mirc21^tm1.1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased bone mass in Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

skeleton

skeleton phenotype ( J:185130 )

N • osteoclast surface is normal

N • mice exhibit normal growth plate development

increased osteoblast proliferation ( J:185130 )

• increased osteoblast proliferation compared with controls

• however, osteoblast apoptosis is normal

increased bone mineral density ( J:185130 )

increased compact bone volume ( J:185130 )

increased compact bone thickness ( J:185130 )

increased osteoblast cell number ( J:185130 )

increased bone mass ( J:185130 )

• at 3 months

abnormal skeleton development ( J:185130 )

• increased bone formation rate compared with controls

enhanced osteoblast differentiation ( J:185130 )

• during embryonic development

abnormal bone mineralization ( J:185130 )

• premature

cellular

enhanced osteoblast differentiation ( J:185130 )

• during embryonic development

increased osteoblast proliferation ( J:185130 )

• increased osteoblast proliferation compared with controls

• however, osteoblast apoptosis is normal