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Phenotypes Associated with This Genotype
Genotype
MGI:5427914
Allelic
Composition		 Gsk3atm1.1Tac/Gsk3atm1.1Tac
Tg(APPV717F)109Ili/0
Tg(Camk2a-cre)#Stl/0
Genetic
Background		 involves: BALB/c * C57BL * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3atm1.1Tac mutation (0 available); any Gsk3a mutation (17 available)
Tg(APPV717F)109Ili mutation (0 available)
Tg(Camk2a-cre)#Stl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:184975 )
• significant decrease in amyloid beta senile plaques compared to transgenic mice wild-type for Gsk3a

behavior/neurological
behavior/neurological phenotype ( J:184975 )
N
• performance in a Barnes maze and in an open field are similar to wild-type controls unlike transgenic mice wild-type for Gsk3a

homeostasis/metabolism
amyloid beta deposits ( J:184975 )
• significant decrease in amyloid beta senile plaques compared to transgenic mice wild-type for Gsk3a

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory