Phenotypes Associated with This Genotype

Genotype
MGI:5427897

• Allelic Composition: Srgap2^Gt(XH102)Byg/Srgap2^Gt(XH102)Byg
• Genetic Background: B6;129P2-Srgap2^Gt(XH102)Byg/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:185134 )

• homozygotes are born at below the expected Mendelian ratio, but are otherwise viable

nervous system

abnormal dendrite morphology ( J:185134 )

• layer 5 cortical pyramidal neurons exhibit an increased density of dendritic spines

abnormal dendritic spine morphology ( J:185134 )

• layer 5 cortical pyramidal neurons exhibit a decreased spine head width and increased length of spine necks