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Phenotypes Associated with This Genotype
Genotype
MGI:5427613
Allelic
Composition		 Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129X1/SvJ
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Mouse lines carrying:
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased oocyte number ( J:183982 , J:192634 )
• much lower numbers at 6 weeks of age (J:183982)
(J:192634)
abnormal meiosis ( J:183982 )
• a subset of unsynapsed chromosome axes are surrounded by H2AFX rich chromatin domains forming pseudo-sex bodies
abnormal female meiosis ( J:192634 )
• pseudo-sex body formation in oocytes is impaired
abnormal synaptonemal complex ( J:236226 )
• extensive non-homologous synaptonemal complex formation

reproductive system
decreased oocyte number ( J:183982 , J:192634 )
• much lower numbers at 6 weeks of age (J:183982)
(J:192634)
abnormal meiosis ( J:183982 )
• a subset of unsynapsed chromosome axes are surrounded by H2AFX rich chromatin domains forming pseudo-sex bodies
abnormal female meiosis ( J:192634 )
• pseudo-sex body formation in oocytes is impaired
abnormal synaptonemal complex ( J:236226 )
• extensive non-homologous synaptonemal complex formation

endocrine/exocrine glands

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory