Phenotypes for Lgr5 Nrbp1 MGI:5427571 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)
Nrbp1^tm1.1Dja mutation (0 available); any Nrbp1 mutation (46 available)
Nrbp1^tm1.2Dja mutation (0 available); any Nrbp1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:184685 )

• authors state that tamoxifen-treated mice exhibit similar phenotype as Nrbp1^tm1.1Dja/Nrbp1^tm1.1Dja Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/ Gt(ROSA)26Sor⁺ mice

abnormal intestinal goblet cell morphology ( J:184685 )

• abnormal goblet cell production in tamoxifen-treated mice

abnormal Paneth cell morphology ( J:184685 )

• abnormal granularization of Paneth cells in tamoxifen-treated mice

ectopic Paneth cells ( J:184685 )

• abnormal localization of Paneth cells in tamoxifen-treated mice

endocrine/exocrine glands