Phenotypes for Pten Tg(Pbsn-cre)4Prb MGI:5427499 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	\Pten^tm1Mro/\Pten⁺ \Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Mro mutation (1 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Prostate cancer progression in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺, Tg(Pbsn-cre)4Prb/0 Pten^tm1Mro/Pten⁺, and Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ mice

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• in 40% of mice at 9 months

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• in 40% of mice at 9 months

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• in 40% of mice at 9 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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