Phenotypes for Agrp Slc17a6 MGI:5427452 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (18 available)
Slc17a6^tm1.1Thna mutation (0 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

• diphtheria-treated mice injected with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries or parabrachial nucleus prevents starvation induced by AgRP neuron ablation unlike in control mice

increased body weight ( J:182577 )

• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus without ablation of AgRP neurons

behavior/neurological

abnormal eating behavior ( J:182577 )

• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus whether treated with diphtheria or not

• in diphtheria treated mice bilaterally with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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