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Phenotypes Associated with This Genotype
Genotype
MGI:5427450
Allelic
Composition		 Agrptm2(HBEGF)Rpa/Agrp+
Tph2tm1Mscl/Tph2tm1Mscl
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm2(HBEGF)Rpa mutation (1 available); any Agrp mutation (17 available)
Tph2tm1Mscl mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal eating behavior ( J:182577 )
• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

growth/size/body
abnormal postnatal growth/weight/body size ( J:182577 )
• diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries prevents starvation induced by AgRP neuron ablation unlike in control mice

homeostasis/metabolism
decreased serotonin level ( J:182577 )
• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory