Phenotypes Associated with This Genotype

Genotype
MGI:5427449

• Allelic Composition: Ffar4^tm1Gdds/Ffar4^tm1Gdds
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:182599 )

• in fasting mice fed a high fat diet

increased circulating insulin level ( J:182599 )

• in fasting mice fed a high fat diet

increased circulating leptin level ( J:182599 )

• in mice fed a high fat diet

increased circulating alanine transaminase level ( J:182599 )

• in mice fed a high fat diet

decreased energy expenditure ( J:182599 )

• in young, but not old, mice fed a high fat diet

increased susceptibility to diet-induced obesity ( J:182599 )

• in mice fed a high fat diet

decreased respiratory quotient ( J:182599 )

• in mice fed a high fat diet during the light phase

impaired glucose tolerance ( J:182599 )

• in mice fed a high fat diet

insulin resistance ( J:182599 )

• in mice fed a high fat diet in an insulin tolerance test

• decreased peripheral tissue insulin sensitivity in mice fed a high fat diet

abnormal lipid level ( J:182599 )

• mice fed a high fat diet exhibit altered lipid composition in the liver, adipose tissue and plasma compared with wild-type mice

• mice fed a normal diet exhibit lower levels of C16:C1n7 palmitoleate in white adipose tissue compared with wild-type mice

increased circulating cholesterol level ( J:182599 )

increased circulating HDL cholesterol level ( J:182599 )

• in mice fed a high fat diet

increased circulating LDL cholesterol level ( J:182599 )

• in mice fed a high fat diet

increased liver triglyceride level ( J:182599 )

• in mice fed a high fat diet

adipose tissue

increased white adipose tissue amount ( J:182599 )

• in mice fed a high fat diet

increased total body fat amount ( J:182599 )

• at 16 weeks in mice fed a high fat diet

increased white fat cell size ( J:182599 )

• in the epididymal and subcutaneous adipose tissue

liver/biliary system

increased liver weight ( J:182599 )

• in mice fed a high fat diet

increased liver triglyceride level ( J:182599 )

• in mice fed a high fat diet

hepatic steatosis ( J:182599 )

• in mice fed a high fat diet

growth/size/body

increased susceptibility to diet-induced obesity ( J:182599 )

• in mice fed a high fat diet

increased liver weight ( J:182599 )

• in mice fed a high fat diet

endocrine/exocrine glands

enlarged pancreatic islets ( J:182599 )

• in mice fed a high fat diet in response to insulin resistance