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Phenotypes Associated with This Genotype
Genotype
MGI:5427104
Allelic
Composition		 Tmc1tm1.1Ajg/Tmc1tm1.1Ajg
Tmc2tm1.1Ajg/Tmc2+
Genetic
Background		 B6.129-Tmc2tm1.1Ajg Tmc1tm1.1Ajg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1tm1.1Ajg mutation (1 available); any Tmc1 mutation (60 available)
Tmc2tm1.1Ajg mutation (1 available); any Tmc2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal hair cell mechanoelectric transduction ( J:184419 )
• significant reduction in transduction current amplitudes in outer hair cells from the P2-P4 basal cochlea

nervous system
abnormal hair cell mechanoelectric transduction ( J:184419 )
• significant reduction in transduction current amplitudes in outer hair cells from the P2-P4 basal cochlea

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory