Phenotypes Associated with This Genotype

Genotype
MGI:5427098

• Allelic Composition: Del(16Lipi-Usp25)1Dja/+
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Del(16Lipi-Usp25)1Dja/+ mice show increased susceptibility to diet-induced obesity

growth/size/body

increased susceptibility to diet-induced obesity ( J:184302 )

• in mice fed a high-fat diet

adipose tissue

increased subcutaneous adipose tissue amount ( J:184302 )

• in mice fed a high-fat diet

increased total body fat amount ( J:184302 )

• in mice fed standard chow or a high-fat diet

increased percent body fat/body weight ( J:184302 )

behavior/neurological

abnormal social investigation ( J:184302 )

• in a 24 hour social memory retention test, mice are less capable of distinguishing between a familiar stimulus normal and an unfamiliar one compared than wild-type mice

liver/biliary system

hepatic steatosis ( J:184302 )

• more severe in mice fed a high-fat diet compared with similarly treated wild-type mice

integument

increased subcutaneous adipose tissue amount ( J:184302 )

• in mice fed a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:184302 )

N • mice exhibit normal whole-body metabolism

increased susceptibility to diet-induced obesity ( J:184302 )

• in mice fed a high-fat diet

taste/olfaction

taste/olfaction phenotype ( J:184302 )

N • mice exhibit normal odor discrimination