Phenotypes Associated with This Genotype

Genotype
MGI:5426964

• Allelic Composition: Cd69^tm1Naka/Cd69^tm1Naka
• Genetic Background: B6.129P2-Cd69^tm1Naka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:184704 )

• fewer CD44^hi CD154+ CD4+ T cells in the bone marrow

abnormal T cell physiology ( J:184704 )

• honing of effector and memory T helper cells to the bone marrow is impaired compared to in wild-type cells

• persistence of T helper cells on bone marrow stromal cells is impaired compared to in wild-type mice

abnormal CD4-positive, alpha-beta T cell physiology ( J:184704 )

• CD4+ T cells fail to induce production of high-affinity antibodies, especially in the late phase, compared with wild-type cells

abnormal memory T cell physiology ( J:184704 )

• bone marrow memory T cells induce less efficiently the production of high-affinity antibodies compared with wild-type cells

abnormal humoral immune response ( J:184704 )

• mice immunized with NP-CGG plus LPS or NP-KLH produce less NP-specific high-affinity antibodies compared with wild-type mice

• however, T follicular helper cells and germinal center B cells are normally generated

decreased interferon-gamma secretion ( J:184704 )

• from CD4+ T cells stimulated with anti-CD3 antibodies in the presence of brefeldin A

decreased tumor necrosis factor secretion ( J:184704 )

• from CD4+ T cells stimulated with anti-CD3 antibodies in the presence of brefeldin A

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:184704 )

• fewer CD44^hi CD154+ CD4+ T cells in the bone marrow

abnormal T cell physiology ( J:184704 )

• honing of effector and memory T helper cells to the bone marrow is impaired compared to in wild-type cells

• persistence of T helper cells on bone marrow stromal cells is impaired compared to in wild-type mice

abnormal CD4-positive, alpha-beta T cell physiology ( J:184704 )

• CD4+ T cells fail to induce production of high-affinity antibodies, especially in the late phase, compared with wild-type cells

abnormal memory T cell physiology ( J:184704 )

• bone marrow memory T cells induce less efficiently the production of high-affinity antibodies compared with wild-type cells