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Phenotypes Associated with This Genotype
Genotype
MGI:5426961
Allelic
Composition		 Ntf3tm2.1Jae/Ntf3tm2Jae
Olig2tm2(cre)Htak/Olig2+
Genetic
Background		 involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm2.1Jae mutation (0 available); any Ntf3 mutation (22 available)
Ntf3tm2Jae mutation (1 available); any Ntf3 mutation (22 available)
Olig2tm2(cre)Htak mutation (0 available); any Olig2 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sensory neuron innervation pattern ( J:182750 )
• axonal projections of Ia afferents do not reach the spinal cord in E15.5 homozygotes
abnormal dorsal root ganglion morphology ( J:182750 )
• cleaved Casp3-positive (apoptotic) neurons are significantly elevated in number in dorsal root ganglia at E10.5 compared to control embryos
abnormal proprioceptive neuron morphology ( J:182750 )
• number of TrkC- or Runx3-positive proprioceptive neurons is decreased in the DRGs at E13.5 compared to heterozygous controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory