Phenotypes Associated with This Genotype

Genotype
MGI:5426938

• Allelic Composition: Wls^tm1Xzg/Wls^tm1Xzg; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:184918 )

• most mice die at weaning due to failure to intake food and water caused by limb defects

limbs/digits/tail

decreased autopod size ( J:184918 )

• truncated

abnormal limb development ( J:184918 )

• at E12.5, mesenchymal cells exhibit decreased proliferation compared with wild-type cells

• at E13.5, distal limbs exhibit increased apoptosis compared with wild-type cells

• mice exhibit dysgenesis of limb soft tissue compared with wild-type mice

abnormal digit development ( J:184918 )

• at E12.5, digit rays fail to extend distally and a continuous ring of distal mesenchyme is retained

short limbs ( J:184918 )

• more severe in forelimbs than hindlimbs

cellular

increased apoptosis ( J:184918 )

• at E13.5, distal limbs exhibit increased apoptosis compared with wild-type cells

decreased cell proliferation ( J:184918 )

• of limb mesenchyme cells at E12.5

behavior/neurological

adipsia ( J:184918 )

• failure to intake food and water caused by limb defects

skeleton

abnormal skeleton morphology ( J:184918 )

• shortened

chondrodystrophy ( J:184918 )

• cartilage hypertrophy delayed

delayed bone ossification ( J:184918 )