Phenotypes Associated with This Genotype

Genotype
MGI:5426541

• Allelic Composition: Lpar2^tm1Dgen/Lpar2^tm1Dgen
• Genetic Background: B6.Cg-Lpar2^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgE level ( J:184061 )

• of ovalbumin-specific IgE following ovalbumin-immunization

abnormal dendritic cell physiology ( J:184061 )

• dendritic cells induce more T cell proliferation and IL13 secretion than wild-type cells

• LPA fails to affect dendritic cell physiology unlike in wild-type cells

• PTX fails to augment the ability of dendritic cells to stimulate T cell proliferation unlike in wild-type cells

• dendritic cells are hyperactive in vitro and in vivo

increased susceptibility to type I hypersensitivity reaction ( J:184061 )

• systemic- and mucosal-immunization induces greater allergic sensitization, airway inflammation and airway hyperresponsiveness compared with wild-type mice

decreased interleukin-10 secretion ( J:184061 )

• from LPS-stimulated dendritic cells

increased interleukin-13 secretion ( J:184061 )

• in the bronchoalveolar lavage fluid following systemic- and mucosal-immunization

increased tumor necrosis factor secretion ( J:184061 )

• from LPS-stimulated dendritic cells

lung inflammation ( J:184061 )

• following systemic- and mucosal-immunization

respiratory system

lung inflammation ( J:184061 )

• following systemic- and mucosal-immunization

increased airway resistance ( J:184061 )

• following systemic- and mucosal-immunization

increased airway responsiveness ( J:184061 )

• following systemic- and mucosal-immunization

hematopoietic system

increased IgE level ( J:184061 )

• of ovalbumin-specific IgE following ovalbumin-immunization