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Phenotypes Associated with This Genotype
Genotype
MGI:5426211
Allelic
Composition		 Smad7tm1.1Ink/Smad7tm1.1Ink
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1.1Ink mutation (1 available); any Smad7 mutation (53 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:184670 )
N
• mice exhibit a largely normal distribution of lymphocyte populations
decreased T cell proliferation ( J:184670 )
• of re-stimulated T cells from MOG 35-55 treated mice
• of T cells stimulated with concanavalin
decreased activated T cell number ( J:184670 )
• small decrease of CD4+ and CD8+ activated T cells in the peripheral lymphoid organs
decreased interferon-gamma secretion ( J:184670 )
• in splenocytes from MOG 35-55-treated mice
decreased interleukin-9 secretion ( J:184670 )
• during Th17 differentiation
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:184670 )
• mice treated with MOG 35-55 exhibit reduced incidence and severity (reduced inflammation, demyelination and axonal damage) of experimental autoimmune encephalomyelitis despite slightly earlier onset of paralysis compared with control mice

homeostasis/metabolism
increased transforming growth factor beta level ( J:184670 )
• in T-cells stimulated with anti-CD3/CD28 and IL2 compared with similarly treated T cells from Tg(CD2-Smad7) mice

behavior/neurological
paralysis ( J:184670 )
• ealier in mice treated with MOG 35-55 compared with control mice

hematopoietic system
decreased T cell proliferation ( J:184670 )
• of re-stimulated T cells from MOG 35-55 treated mice
• of T cells stimulated with concanavalin
decreased activated T cell number ( J:184670 )
• small decrease of CD4+ and CD8+ activated T cells in the peripheral lymphoid organs

cellular
decreased T cell proliferation ( J:184670 )
• of re-stimulated T cells from MOG 35-55 treated mice
• of T cells stimulated with concanavalin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory