Phenotypes Associated with This Genotype

Genotype
MGI:5425955

• Allelic Composition: A4gnt^tm1Jnaka/A4gnt^tm1Jnaka
• Genetic Background: B6.129S6-A4gnt^tm1Jnaka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hyperplasia, dysplasia and adenocarcinoma in A4gnt^tm1Jnaka/A4gnt^tm1Jnaka pyloric mucosa

digestive/alimentary system

abnormal stomach mucosa morphology ( J:184485 )

• increased stomach mucosal thickness compared to in wild-type mice

stomach epithelial hyperplasia ( J:184485 )

• of pyloric epithelial cells in the gastric antrum

increased gastric adenocarcinoma incidence ( J:184485 )

• in the antrum as early as postnatal week 5

• in the pyloric mucosa but not the fundic mucosa of the gastric corpus

• at 10 weeks, low-grade dysplasia and slight glandular distortion

• at 20 weeks, high-grade dysplasia with marked glandular complexity

• at 30 weeks, well-differentiated gastric adenocarcinoma invading the lamina propria

• at 50 weeks, all mice exhibit adenocarcinomas

abnormal digestive system physiology ( J:184485 )

• epithelial cells in the pyloric mucosa exhibit increased cell proliferation compared with wild-type cells

stomach inflammation ( J:184485 )

• in the gastric mucosa

neoplasm

increased gastric adenocarcinoma incidence ( J:184485 )

• in the antrum as early as postnatal week 5

• in the pyloric mucosa but not the fundic mucosa of the gastric corpus

• at 10 weeks, low-grade dysplasia and slight glandular distortion

• at 20 weeks, high-grade dysplasia with marked glandular complexity

• at 30 weeks, well-differentiated gastric adenocarcinoma invading the lamina propria

• at 50 weeks, all mice exhibit adenocarcinomas

increased tumor growth/size ( J:184485 )

• with age

cellular

increased cell proliferation ( J:184485 )

• of epithelial cells in the pyloric mucosa

cardiovascular system

increased angiogenesis ( J:184485 )

• in the gastric mucosa

immune system

stomach inflammation ( J:184485 )

• in the gastric mucosa