Phenotypes Associated with This Genotype

Genotype
MGI:5424779

• Allelic Composition: Gga1^{Gt(AN0619)Wtsi}/Gga1^{Gt(AN0619)Wtsi}; Gga3^{Gt(RRC067)Byg}/Gga3^{Gt(RRC067)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased birth weight ( J:184229 )

slow postnatal weight gain ( J:184229 )

• gained weight even more slowly than the single nulls, and at 20 weeks exhibited a 38% reduction in weight compared to controls

mortality/aging

neonatal lethality, incomplete penetrance ( J:184229 )

• 47% neonatal lethality

postnatal lethality, incomplete penetrance ( J:184229 )

reproductive system

reduced fertility ( J:184229 )

• adult survivors have a normal lifespan but exhibit extremely poor fertility

homeostasis/metabolism

hypoglycemia ( J:184229 )

• exhibit hypoglycemia on postnatal day 1

abnormal circulating enzyme level ( J:184229 )

• a marginal elevation (1.6 to 2.2 fold) in plasma levels of a subset of the acid hydrolases