Phenotypes Associated with This Genotype

Genotype
MGI:5319775

• Allelic Composition: Fst^tm1Zuk/Fst⁺
• Genetic Background: B6.129S7-Fst^tm1Zuk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal extensor digitorum longus morphology ( J:182827 )

• increase in the percentage of oxidative type I fibers

decreased quadriceps weight ( J:182827 )

abnormal gastrocnemius morphology ( J:182827 )

• increase in the number of oxidative type I fibers

decreased gastrocnemius weight ( J:182827 )

abnormal skeletal muscle fiber morphology ( J:182827 )

• increase in the proportion of smaller fibers that stain more darkly in hematoxylin and eosin stained sections corresponding to mixed glycolytic/oxidative type IIa fibers

• shift towards more oxidative fibers

• decrease in mean fiber diameter for each fiber type

decreased skeletal muscle weight ( J:182827 )

• about 15-20% lower than wild-type

• decreased triceps weight

abnormal pectoral muscle morphology ( J:182827 )

• decreased weight

abnormal muscle physiology ( J:182827 )

• lower twitch and tetanic force production

• but no change in specific force

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:182827 )

• impaired muscle regeneration and enhanced fibrosis in the gastrocnemius muscle following cardiotoxin-induced injury

limbs/digits/tail

abnormal extensor digitorum longus morphology ( J:182827 )

• increase in the percentage of oxidative type I fibers

decreased quadriceps weight ( J:182827 )

abnormal gastrocnemius morphology ( J:182827 )

• increase in the number of oxidative type I fibers

decreased gastrocnemius weight ( J:182827 )