Phenotypes Associated with This Genotype

Genotype
MGI:5319313

• Allelic Composition: Nr2e1^frc/Nr2e1^frc
• Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:183689 )

• reduced numbers of vessels with radial asymmetry

abnormal retina ganglion cell morphology ( J:183689 )

• dispersed in the inner plexiform layer

thin retina inner nuclear layer ( J:183689 )

thin retina outer nuclear layer ( J:183689 )

abnormal eye electrophysiology ( J:183689 )

• mice exhibit reduced to absent a-wave and b-wave signals unlike wild-type mice

nervous system

abnormal neuronal precursor proliferation ( J:183689 )

• decreased in the lateral ventricle and dentate gyrus

abnormal cerebral hemisphere morphology ( J:183689 )

• decreased size

small olfactory bulb ( J:183689 )

abnormal retina ganglion cell morphology ( J:183689 )

• dispersed in the inner plexiform layer

cardiovascular system

abnormal retina vasculature morphology ( J:183689 )

• reduced numbers of vessels with radial asymmetry

cellular

abnormal neuronal precursor proliferation ( J:183689 )

• decreased in the lateral ventricle and dentate gyrus