Phenotypes Associated with This Genotype

Genotype
MGI:5319212

• Allelic Composition: Tle3^tm1Jcc/Tle3^tm1Jcc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:183486 )

• vast majority die at E14.5

embryo

decreased embryo size ( J:183486 )

abnormal placenta morphology ( J:183486 )

• placental defects

endocrine/exocrine glands

abnormal pancreatic alpha cell morphology ( J:183486 )

• expression analysis indicates reduced induction of alpha cells in rare surviving mice at E14.5 and E17.5

abnormal pancreatic beta cell morphology ( J:183486 )

• expression analysis indicates reduced induction of beta cells in rare surviving mice at E14.5 and E17.5

abnormal pancreatic epsilon cell morphology ( J:183486 )

• clusters of ghrelin+ cells are seen at E14.5 but cultured explants from E12.5 embryos lack ghrelin+ cells

abnormal pancreas development ( J:183486 )

• pancreas explants from E12.5 embryos expand and branch normally but lack almost all endocrine cell types

abnormal PP cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic alpha cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic beta cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic delta cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic epsilon cell differentiation ( J:183486 )

• severely impaired in cultured explants

small pancreas ( J:183486 )

• at E12.5 and E13.5

growth/size/body

decreased embryo size ( J:183486 )

cellular

abnormal PP cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic alpha cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic beta cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic delta cell differentiation ( J:183486 )

• severely impaired in cultured explants

abnormal pancreatic epsilon cell differentiation ( J:183486 )

• severely impaired in cultured explants